Label-Retaining Stromal Cells in Mouse Endometrium Awaken for Expansion and Repair After Parturition
نویسندگان
چکیده
منابع مشابه
Identification, characterization and co-localization of label-retaining cell population in mouse endometrium with typical undifferentiated markers.
BACKGROUND The endometrium, lining of the uterus, is a highly active organ that is remodelled periodically during the lifespan. Different studies suggest the presence of an adult or progenitor stem cell (PSC) population in this tissue because of its cyclic regenerative capacity. METHODS In this study, we aim at identifying and localizing the putative PSC population in the murine uterus using ...
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Individual tumour cells display diverse functional behaviours in terms of proliferation rate, cell-cell interactions, metastatic potential and sensitivity to therapy. Moreover, sequencing studies have demonstrated surprising levels of genetic diversity between individual patient tumours of the same type. Tumour heterogeneity presents a significant therapeutic challenge as diverse cell types wit...
متن کاملLabel-retaining epithelial cells in mouse mammary gland divide asymmetrically and retain their template DNA strands.
It has been postulated that the stem cells of somatic tissues protect themselves from mutation and cancer risk by selective segregation of their template DNA strands. Self-renewing mammary epithelial stem cells that were originated during allometric growth of the mammary ducts in pubertal females were labeled using [3H]-thymidine (3HTdR). After a prolonged chase during which much of the branchi...
متن کاملLabel-retaining cells and tubular regeneration in postischaemic kidney.
BACKGROUND In this study, we have examined rat kidneys after ischaemic injury (35 min) with regard to the dynamics of S3 tubule regeneration. METHODS One day before ischaemia, each rat received four successive i.p. injections of BrdU (5-bromo-2'-deoxyuridine: 80 mg/kg) at 2 h intervals. Groups of experimental animals (n = 4) were killed every 2 h during the first 24 h post-ischaemia as well a...
متن کاملIn vivo phenotypic characterisation of nucleoside label-retaining cells in mouse periosteum.
Periosteum is known to contain cells that, after isolation and culture-expansion, display properties of mesenchymal stromal/stem cells (MSCs). However, the equivalent cells have not been identified in situ mainly due to the lack of specific markers. Postnatally, stem cells are slow-cycling, long-term nucleoside-label-retaining cells. This study aimed to identify and characterise label-retaining...
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ژورنال
عنوان ژورنال: Stem Cells and Development
سال: 2015
ISSN: 1547-3287,1557-8534
DOI: 10.1089/scd.2014.0225